In a preclinical study, HER2 and αVβ3 CAR-T cells induced death in human and murine GBM cells and, in CD133+ GSCs, increased the production of pro-inflammatory cytokines, such as IFN-γ, TNF-α, and IL-2, in co-culture experiments in vitro. This evidence concerns the gene PROM1 and glioblastoma.