PTH and Hypocalcemia: Endocrine-related side effects associated with these agents include alterations in thyroid function (hypothyroidism, hyperthyroidism, and thyroiditis), bone metabolism in response to dysregulation of calcium and phosphate metabolism developing hypocalcemia, and 25-OH vitamin D deficiency with secondary parathormone (PTH) elevation, linear growth, gonadal function, fetal development, glucose metabolism, and adrenal function [58,59].