ExoPD-L1 can be produced by different cell types, tumor, and non-tumor, and have a greater immunosuppressive effect compared to other forms of sPD-L1 due to their interaction via exosomal MHC I with the TCR, which mimics the effect of the tumor surface PD-L1 [14,15,16,17,18,19,20,21]. The gene discussed is SPDL1; the disease is neoplasm.