Even though sPD-L1 is mostly derived from the membrane cleavage of tumor PD-L1 [15], other sources of PD-L1, such as myeloid cells and activated T cells, have high levels of membrane PD-L1, with myeloid cells being the immune cells with the greatest capacity to release sPD-L1 [16]. The gene discussed is CD274; the disease is neoplasm.