Overall, our evidence is in keeping with the notion that autophagy exerts a primary cytoprotective role in response to different stimuli, including anticancer therapies [48] as well as with recent findings showing that RHPS4-induced telomeric damage fuels the overactivation of telomeric recombination (i.e., increased ALT activity) in osteosarcoma cells [49]. The gene discussed is GPT; the disease is osteosarcoma.