NGFR and early-onset autosomal dominant Alzheimer disease: Of interest for the present study, p75NTR may undergo regulated cleavage, generating intracellular fragments able to translocate to the nucleus harboring specific signaling activity, as already demonstrated for the pro-apoptotic activity of the p75NTR Intracellular Domain (p75ICD), released upon the γ- and α- secretases’ sequential cleavages of the p75NTR in neurodegenerating neurons of Alzheimer’s Disease-affected brains [8].