Therefore, our study showing that the p75NTR and expression patterns differ in a stage-specific and zone-related manner, and that p75ICD is co-localized with the metastatic marker ABCG2 and shows a prevalent nuclear expression in aberrant and highly dysmorphic cancer cells, led us propose p75ICD as a good candidate prognostic factor in LSCC. This evidence concerns the gene NGFR and cancer.