Moreover, the anti-proliferative effect of p75NTR knockdown in cancer cells has been found to be mediated by the regulation of the p53 tumor suppression [11], which has been recently reported as an independent prognostic factor in HNSCC patients [12], further supporting the role of p75NTR in the progression of squamous carcinomas. This evidence concerns the gene NGFR and head and neck squamous cell carcinoma.