Given that our study found that Kv1.3 is highly expressed in resected PDAC, it is possible that during the transition to a metastatic phenotype, pancreas cancer cells are able to down regulate Kv1.3, possibly due to methylation of the promoter region of the Kcna3 gene encoding for Kv1.3, or another unexplained mechanism [27]. Here, KCNA3 is linked to pancreatic neoplasm.