TGFB1 and neoplasm: Three isoforms of TGFβ (TGFβ 1, TGFβ 2, and TGFβ 3) instigate cellular phenotypical changes through canonical (SMAD) and non-canonical (MAPK, JAK/STAT, and PI3K/Akt) signalling pathways that mediate its role both as a tumour suppressor and a tumour promoter.