TNF and rheumatoid arthritis: Notably, it has been reported that TNF inhibition by neutralizing monoclonal antibodies such as Infliximab and Adalimumab leads to increased blood Tregs in patients with rheumatoid arthritis (RA) [66], and another study showed that exogenous sTNF reduces the inhibitory effect of Tregs from HBV (hepatitis B virus) patients [67].