Not only is HER2 signaling essential for maintaining the homeostasis of the HER2-rich cardiomyocytes [12], it is also required for surviving the oxidative stress elicited by anthracycline chemotherapies [13], which ultimately leads to dilated cardiomyopathy when trastuzumab is given concomitantly with doxorubicin [14]. The gene discussed is ERBB2; the disease is dilated cardiomyopathy.