Such differences in terms of ED-B isoform expression between TY-82 cell line (pure epithelial cells) and the two primary cultures derived from recurrent TET patients (aggressive phenotypes), together with literature data—it has been recently shown that thymoma cells may undergo EMT [39], and we had showed that epithelial-to-mesenchymal transition (EMT) induces ED-B FN expression [37]—further supported the speculation that the overexpression of ED-B FN in TETs is related to EMT and the acquisition of more aggressive phenotypes. The gene discussed is FN1; the disease is thymoma.