Two weeks after subcutaneous injection of 1.0 × 106 RNF125-depleted LPCs into the flanks of mice, visible tumors started to form in transplanted mice, while LPCs transduced with negative control (NC) shRNA did not induce tumors (Figure 2A), clearly indicating that RNF125 acts as a tumor suppressor. Here, RNF125 is linked to neoplasm.