In the present study, in salivary gland duct adenocarcinoma gland-like structures, the expression of CGN and ZO-3, but not p63, was detected, and OLFML3 was decreased in the cancer cells compared to normal ones, while in the solid type of salivary gland duct adenocarcinoma, CGN, ZO-3, and OLFML3 were not detected, while p63 was detected in some cancer cells. Here, OLFML3 is linked to cancer.