Comparing adjacent and tumor tissues in the different tumor locations, the positivity for ACE2 was similar in both contexts (non-neoplastic colon mucosa 50/60 (92.6%), non-neoplastic gastric mucosa 16/19 (84.2%), and normal thyroid follicles 0/11 (0%)) (Supplementary Figure S1). Here, ACE2 is linked to neoplasm.