STING1 and cancer: In this context, chronic DAMP-induced PRR/STING activation leads to persistent low-dose IFN-β autocrine and paracrine stimulation of cancer cells, which induces UISGF3-mediated transcription of the non-canonical pathway that overlaps with the IRDS (STAT1, ISG15) and includes RIG-I and MDA5 [32].