CBX8 and colorectal carcinoma: More importantly, our supplementary experiments showed that CBX8 overexpression in the CRC cell line HCT116 induced the protein level of c-MYC (Supplementary Figure S2), as well as repressed the level of let-7, which is reported to downregulate c-MYC in CRC as well as being down-regulated by c-MYC via LIN28 repression [49].