CBX8 and cancer: Previous studies demonstrated that CBX8 is overexpressed in CRC and it functionally induces CRC cell proliferation and inhibits tumor apoptosis [11,12], and CBX8 is associated with cancer stemness and chemoresistance in CRC [13], yet the prognostic potential of tumor CBX8 expression for the survival of CRC patients was ambiguous among current reports [12,16,17].