We found that patients with familial hypercholesterolemia (FH) presenting subclinical lipid-rich atherosclerotic plaques have significantly higher amounts of circulating lymphocyte-derived (CD3+/CD45+) EVs than FH patients with fibrous plaques [50] in agreement with other studies that reported high levels of EVs from T lymphocytes in subjects with essential hypertension [235] and about to develop a MACE [265]. Here, PTPRC is linked to familial hypercholesterolemia.