CDKN1A and melanoma: Apoptosis facilitators (such as PUMA and p21waf1 (also known as wild-type p53-activated fragment 1: WAF1) [115]), increased rapidly following the preclinical treatment of melanoma with mEHT and a significant reduction in tumor size was observed following a stress response signaled by iHSP70 and mHSP70 [107].