In a recent study, Huang et al. generated an EC-specific PDGFR-β knockout transgenic mouse model and found a PDGF–NF-κB–HIF1-α–Snail axis that promotes VE-cadherin down-expression and activates mesenchymal-like transcriptional mechanisms and vessel abnormalities after myocardial infarction (MI) [104]. The gene discussed is CDH5; the disease is myocardial infarction.