Various stimuli, endothelin-1, angiotensin II, glucose, advanced glycation end-products, and inflammatory stimuli such as inflammatory mediators, growth factors, hypoxia, and proteases, can induce EndoMT via TGF-β signaling, which plays a vital role during the development of cardiovascular diseases [91,115,116,117,118,119,120]. Here, TGFB1 is linked to cardiovascular disorder.