NGF and early-onset autosomal dominant Alzheimer disease: It is worth noting, though, that the expression of anti-NGF antibodies in the adult brain of transgenic mice, determines a progressive neurodegeneration with synaptic and behavioral deficits, and with neurodegeneration hallmarks reminiscent of an Alzheimer’s disease-like phenotype, an effect much broader than what one would expect based on the action of these antibodies exclusively on the cholinergic system [23].