GLIS2 and metabolic dysfunction-associated steatohepatitis: The study further indicates that GLIS2 plays a critical role in promoting NASH-associated reprogramming in hepatocytes by repressing the expression of hepatocyte identity genes (e.g., Cyp8b1, Aldh2, Idh1, and Slc2a2) and increasing that of inflammatory and fibrosis-related genes (Figure 4B) [41].