Among the genes regulated by CBFA2T3-GLIS2 were those with established roles in leukemia and hematopoietic stem cell self-renewal and the control of EMT and cell migration, including genes linked to the NOTCH, sonic hedgehog (SHH), WNT, hippo, and TGFβ/BMP signaling pathways [13,33,35,80,81]. Here, GLIS2 is linked to leukemia.