Several studies demonstrated that a cryptic inversion of chromosome 16 that fuses CBFA2T3 to GLIS2, is frequently (25–30%) associated with a pediatric non-Down’s syndrome (non-DS) acute megakaryoblastic leukemia (AMKL) with poor prognosis [32,34,75,76,77,78,79,80]. The gene discussed is GLIS2; the disease is acute megakaryoblastic leukemia.