DRD1 and Anxiety: Additionally, of particular importance for the aim of this work is the finding that JMV2959, a GHSR1a antagonist, when is simultaneously injected with SKF81297 into the hippocampus, prevented the D1R-induced extinction memory consolidation [317], signifying that GHSR1a protomers may have a facilitating action on the modulation of anxiety through their allosteric interactions with D1R protomers within GHSR1-D1R localized within the hippocampus and perhaps in the amygdala and other brain regions.