As the strongly anxiogenic Gal (1–15) fragment binds to the GalR1-GalR2 heterodimer, it will be of interest, as in the case of depression (see above), to clarify the role of Gal (1–29) vs. the galanin fragment (1–15) in the modulation of the GalR1-GalR2-5-HT1A and GalR1-GalR2 heterocomplexes. The gene discussed is GAL; the disease is major depressive disorder.