In situ hybridization studies have reported that mRNA encoding GHSR1a is largely expressed in the brain [295,309,310], where it has been particularly found in the ventral tegmental area (VTA) and some limbic regions such as the hippocampus, nucleus accumbens, and amygdala, which are known to be linked to modulation of depression and anxiety (see above). The gene discussed is GHSR; the disease is depressive symptom measurement.