On the other hand, while COX-2 overexpression in adipocytes leads to protection against diet-induced obesity and inflammation, and COX-2 in adipocytes mediates the anti-inflammatory benefits of intermittent fasting [38,39], whether endogenous COX-2 in adipocytes is implicated in adiposity and obesity is unclear. Here, PTGS2 is linked to obesity due to melanocortin 4 receptor deficiency.