To interrogate the role of Dino in suppressing T cell lymphoma directly, we utilized a model of thymic lymphomagenesis induced by exposure to ionizing radiation at a dose that effectively induces thymic T cell lymphomas in p53+/+ mice [31] and which is significantly accelerated by the loss of p53, demonstrating that p53-dependent tumor suppression is essential in this model [28,32]. This evidence concerns the gene TP53 and neoplasm.