DINOL and bone sarcoma: In this study, we examined the function of Dino in tumor suppression by assessing the susceptibility of Dino-null mice to the formation of spontaneous tumors, revealing a predisposition towards the development of soft tissue and bone sarcoma, B lymphomas and other rare tumors, providing to our knowledge the only rigorous, genetic evidence that loss of lncRNA is sufficient to promote spontaneous tumorigenesis.