Overall, these findings demonstrate that when GSK-3β activity is restrained through the BCR/PI3Kδ/PDK1/Akt axis, the optimal fitness of lymphoma cells is bolstered via c-Myc, a phenomenon which is reminiscent of the mechanisms controlling proliferation and survival of more mature healthy B-cells in GCs (see Section 2.1). The gene discussed is PDK1; the disease is lymphoma.