CD34 and chronic myelogenous leukemia, BCR-ABL1 positive: It was demonstrated that GSK-3β is constitutively phosphorylated at Tyr 216 (hence active) and predominantly located in the cytoplasm of CD34+ CML LSCs, while CD34+ HSCs from healthy donors did express some Tyr 216 (hence active) p-GSK-3β, but also displayed Ser 9 (hence inactive) p-GSK-3β [112].