Interestingly, a selective inhibitor of Proviral integration site for Moloney murine leukemia virus-1 (PIM-1) kinase (SMI-4a) decreased the levels of GSK-3β phosphorylated on Ser 9 and inhibited nuclear translocation of β-catenin in both K562 and imatinib-resistant K562 (K562/G) CML cell lines [110]. This evidence concerns the gene GSK3B and chronic myelogenous leukemia, BCR-ABL1 positive.