A recent study by Donega and co-workers used the surface marker CD271 for isolating several thousand SVZ progenitors from control and PD patients [37], and a similar strategy could be used to isolate and sequence microdomain specific cells from the human SVZ from control and MS patients, perhaps by combining a surface marker such as CD271 with other markers to enrich specifically for NSCs, whilst also capturing additional cell types present in the niche. This evidence concerns the gene NGFR and Parkinson disease.