EGF signaling is important for astroglial activation and priming for neurogenesis [50], and therefore upregulation of LRIG1 in human AD (logFC = 0.882, p = 0.0087) and downregulation in zebrafish (logFC = −0.353, p = 4.1 × 10−6) can point towards a differential neurogenesis response in humans and zebrafish. The gene discussed is EGF; the disease is Alzheimer disease.