Overexpression of c-Myc would change the expression of a series of related genes, such as increasing the levels and activities of snail and vimentin, and reducing the level and activity of E-cadherin, thus leading to low expression of the tumor suppressor gene Chibby, which leads to laryngeal squamous cell carcinoma [46]. This evidence concerns the gene CBY1 and laryngeal squamous cell carcinoma.