To our surprise, despite severe HTG and elevated plasma cholesterol levels, Ldlr−/− mice receiving P407 for seven weeks compared with controls had significantly less atherosclerosis, as evidenced by the reduced plaque size in whole aortas, aortic sinus (Figure 2A,B), and BCA (Supplementary Figure S2) examined by oil red O staining. The gene discussed is LDLR; the disease is atherosclerosis.