AKT1 and breast cancer: For instance, whereas mPRα-mediates reversal of epithelial to mesenchymal transition (EMT) through PI3K and EGFR pathways in MDA-MB-468 breast cancer cells [62], mPRα-dependent activation of PI3K/AKT/mTOR signaling in MDA-MB-453 breast cancer cells transfected with breast cancer resistance protein (BCRP) resulted in increased BCRP expression which would promote breast cancer metastasis [40].