For example, activation of these mPR-dependent signaling pathways inhibits apoptosis and cell death in fish ovarian follicle cells and human neuronal and breast cancer cells [29,37,50], which is not unexpected since PI3K/AKT and MAPkinase exert antiapoptotic actions and promote cell survival in numerous mammalian cells [61]. This evidence concerns the gene AKT1 and breast carcinoma.