Tumor-cell-derived exosomes carrying MiR-21-5p can inhibit the interaction between Krev and capture protein 1 (KRIT1) in HUVECs and activate the β-linked protein signaling pathway by increasing the downstream targets VEGFa and CCND1, thereby promoting angiogenesis and vascular permeability in CRC [56]. The gene discussed is VEGFA; the disease is neoplasm.