Downregulation of TG2 led to a decrease in actin stress fiber formation, RCC cells’ adhesion to β1 integrin substrates fibronectin, collagen type I and laminin, and diminished the expression of CD44, CD73-and CD105 CSC markers, supporting that TG2 impacts cancer cell adhesion, migration, invasiveness and cancer cell-stemness during RCC progression and dissemination [58]. The gene discussed is CD44; the disease is cancer.