Cao and colleagues demonstrated that TGF-β, a cytokine abundantly increased in the OC microenvironment, regulates NF-κB signaling activation that in turn upregulates TG2 expression, induces EMT, enhancing the percentage of CD44+/CD117+ cells which is important to cell aggregation as spheroids, the main vehicle of OC tumor dissemination [42]. Here, TGM2 is linked to neoplasm.