SNAI1 and breast cancer: BC cell lines transfected with GTP-binding-deficient TG2 mutant (R580A) displayed strong overexpression of E-cadherin and a concomitant decrease in mesenchymal markers expression, such as N-cadherin, vimentin, and FN, and the downregulation of transcription repressors Snail1, Zeb 1/2, and Twist 1 compared to cells transduced with wild-type (TG2-WT) or transamidating mutant constructs (TG2-C277S).