Cao and colleagues demonstrated that TGF-β, a cytokine abundantly increased in the OC microenvironment, regulates NF-κB signaling activation that in turn upregulates TG2 expression, induces EMT, enhancing the percentage of CD44+/CD117+ cells which is important to cell aggregation as spheroids, the main vehicle of OC tumor dissemination [42]. The gene discussed is CD44; the disease is neoplasm.