Moreover, pulmonary fibrosis and epithelial/mesenchymal crosstalk, in the case of non-small-celllung cancer (NSCLc), mediated by Shh, result in an elevated production ofECM-related proteins, such as fibronectin and fibroblast collagen [17,101], which reflects the indirect involvement of Shh in airway remolding (Figure 5) [102]. This evidence concerns the gene SHH and pulmonary fibrosis.