SERPINE1 and age-related macular degeneration: Consistent with findings in an earlier study by our group, where we demonstrated the significant effect of rs704 on vitronectin protein expression and processing, and a role in angiogenesis-related processes such as ECM remodeling and cell migration [8], we now focused on the rs704-related vitronectin isoforms (non-AMD risk-associated VTN_rs704: C and AMD risk-associated VTN_rs704: T) and their interaction with the angiogenic regulator PAI-1.