Our findings, in conjunction with previous observations [8,42,44,108], led us to propose a conceptual disease model for neovascular AMD (Figure 6), in which the risk-associated rs704: T genotype in combination with ageing would lead to a significant increase in vitronectin and PAI-1 protein expression, eventually contributing to vascular changes in this late-stage AMD phenotype. The gene discussed is SERPINE1; the disease is age-related macular degeneration.