Initially, the association of genetic variation in or near the PAI-1 gene at 7q21.3–q22 was assessed in the IAMDGC dataset and revealed a signal with nominal significance at this locus, exclusively carried by the NV-AMD association (variant with smallest p-value rs28709821, p = 2.71 × 10−6) (Supplementary Figure S3). The gene discussed is SERPINE1; the disease is age-related macular degeneration.