In support of this concept, mTOR upregulation, which is commonly observed as a drug resistance mechanism in a broad range of tumor types [16,17], blocks the autophagy pathway at various steps [18] and renders tumors cells hypersensitive to well-tolerated doses of metabolic inhibitors that have little to no effect on normal autophagy-competent cells [19]. The gene discussed is MTOR; the disease is neoplasm.