CD40LG and systemic lupus erythematosus: All these findings outline an important signature for the CD154–CD40 dyad in a wide range of inflammatory responses [15,27,35], some of which lead to the pathogenic process of chronic inflammatory autoimmune diseases, including rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis [61], autoimmune thyroiditis [62], Sjögren’s syndrome [63], type I diabetes [64,65], polymyositis, dermatomyositis [66], leprosy [67], inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis [68], as well as vascular diseases such as atherosclerosis and restenosis [48,49,65,69].