Acute lymphoblastic leukemia (ALL) T cells exhibited an increased survival rate and an enhanced migration upon stimulating their α2β1 integrins with collagen type I in a mechanism dependent upon ERK1/2 MAPK activation and maintenance of the Bcl-2 family member, prosurvival protein, Mcl-1 [140]. This evidence concerns the gene MCL1 and acute lymphoblastic leukemia.