Five CpGs: cg19760734 (TACC1), cg05876416 (FAM173B), cg00234736 (ELMO1), cg21243612 (C9orf6), and cg24040188 (RBBP8) consistently appeared among the four AI algorithms (SVM, PAM, RF and DL) for AD detection (Table 1). The gene discussed is RBBP8; the disease is Alzheimer disease.