Upregulated proteins were DNAJC13, GPI, ANPEP, COTL1, GCA, GSTP1, PNP, PGAM1, TBMBS4X and APOA1, while downregulated proteins were AHSG, PROS1, SERPINA3, MPO, MMRN1 and DEFA1 in sepsis patients compared to w/o sepsis and HC. The gene discussed is COTL1; the disease is Sepsis.