NETs formation and cell-free DNA were found to be increased in sepsis patient plasma supernatants, with the rise in IL-8, IL-10, IL-18, etc., and a decline in IL-1β, IL-2, IL-4, etc. cytokines and DNAJC13, GPI, GSTP1, PNP, ANPEP, COTL1, GCA, PGAM1, TBMBS4X, and APOA1 proteins which play important roles in neutrophil activation and its immune response. Here, IL2 is linked to Sepsis.