However, few downregulated proteins in sepsis patients compared to HC were AHSG, and PROS1, whereas compared to w/o sepsis, patients were AHSG, PROS1, DEFA1, SERPINA3, MPO, and MMRN1 (Azurophil granule, azurophil granule lumen and secretory granule lumen (GO:0042582, GO:0035578 and GO:0034774)) (Figure 5D). Here, DEFA1 is linked to Sepsis.