In addition, α-Syn aggregates were related to numerous neurodegenerative disorders, collectively termed “synucleinopathies”, such as dementia with LBs, multiple system atrophy, pantothenate kinase-associated neurodegeneration, frontotemporal dementia, diffuse LB disease, amyotrophic lateral sclerosis (ALS), Parkinsonism dementia complex of Guam, pure autonomic failure, progressive supranuclear palsy, corticobasal degeneration, and Krabbe disease (reviewed in [24,25]). This evidence concerns the gene PANK1 and amyotrophic lateral sclerosis.