Particularly, mutations in genes encoding lysosomal hydrolases and their delivery (e.g., GBA1 encoding acid-β-glucosidase, glucocerebrosidase), lysosome acidification (e.g., ATP6AP2 encoding ATPase H+ transporting accessory protein 2 and ATP13A2 encoding ATPase 13A2 cation transporting), and lysosomal ion channels or transporters (TMEM175 encoding lysosomal K+ channel) are associated with PD development [236,237,238]. The gene discussed is GBA1; the disease is Parkinson disease.