In another GWAS, an intergenic single nucleotide polymorphism on chromosome 7 (rs111720447, C/A), which is located near glucocorticoid receptor binding sites, has been shown to be strongly associated with lung function decline in the inhaled corticosteroid (ICS) treatment group of COPD patients [48]. The gene discussed is NR3C1; the disease is chronic obstructive pulmonary disease.