In line with findings by Achuta et al. (2018) of abnormal glutamatergic transmission in FXS [59], Brighi et al. (2021) found that a local application of glutamate triggered a significantly higher increase in intracellular calcium levels in neurons derived from FMR1-knockout human iPSC than in FMRP-expressing neurons [24]. The gene discussed is FMR1; the disease is fragile X syndrome.