A small-molecule screening study revealed that FMR1 reactivation in FXS-iPSCs and FXS-iPSC-derived NPCs by 5-azadC was enhanced if used in combination with 3-deazaneplanocin A (DZNep), an inhibitor of both S-adenosyl-homocysteine (SAH) hydrolase and histone methylation [69]. The gene discussed is FMR1; the disease is fragile X syndrome.