In addition, it has been found that probiotics such as Lactobacillus plantarum ZDY2013 and Bifidobacterium bifidum WBIN03 can regulate the secretion of antioxidant enzymes, SOD1, GPX2 and CAT, by activating the Nrf2 pathway, while achieving the effect of alleviating colitis [50]. The gene discussed is SOD1; the disease is colitis.