NFKB1 and ulcer disease: Probiotics such as lactobacillus and Bifidobacterium are known to be able to regulate the immune function of the gastrointestinal tract and inhibit NF-κB activation [46], prevent exogenous stimuli and the invasion of harmful bacteria, decrease intestinal permeability and contribute to the regeneration of vascular endothelial factors, thereby promoting the healing of gastric mucosa and assisting in the treatment of ulcers [37,38,39,40,41,42,43,44,45,46,47,48,49].