AGTR1 and endothelial dysfunction: One target of Ang II and Ang II type 1 receptors (AT1R) is Rho kinase (ROCK), which can produce endothelial dysfunction via inhibitory effects on endothelial NO synthase (eNOS) and other mechanisms (Amin et al., 2013; Budzyn et al., 2006; De Silva et al., 2016, 2017, 2018, 2018; Sawada & Liao, 2014).