Conversely, CXCR4 overexpression strikingly counteracted the effect of PTX on decreasing Akt phosphorylation and reductions in N-cadherin, vimentin, snail, CD44, CD133, and NANOG protein expression in SKOV3 tumor tissues (Figures 7C, 7D, 8B and Supplementary Figure 7B; *P<0.05). Here, NANOG is linked to neoplasm.