AKT1 and neoplasm: Clearly, both WB and IF showed that shRNA silencing CXCR4 synergistically enhanced the effect of PTX treatment on decreasing Akt phosphorylation and the resulting reduction in N-cadherin, vimentin, snail, CD44, CD133, and NANOG protein expression in OVCA420 tumor tissues (Figure 7A, 7B, Figure 8A).