The underlying mechanism involves the cAMP-dependent protein kinase A signaling pathway [33], cyclo-oxygenase-2 signaling pathway [34], osteoblast-specific expression of Fra-2/AP-1 pathway [35], etc. Longitudinal evidence in terms of this topic is lacking, especially among patients with type 2 diabetes. The gene discussed is PTGS2; the disease is type 2 diabetes mellitus.