For the five stemness model genes identified in this study, COLEC12 has been suggested as a prospective biomarker for anaplastic thyroid cancer [80], and Li et al. reported that knockdown of COLEC12 could promote apoptosis and enhance inflammation through TLR4 in osteosarcoma [81]. Here, TLR4 is linked to thyroid gland undifferentiated (anaplastic) carcinoma.