In an analysis where we further adjusted for eGFR, insulin, hsCRP and leptin, the association between MR-proADM and incident type 2 diabetes was attenuated, but remained significant in obese participants (HRs [95% CIs] per 1-SD increase of log MR-proADM: 1.14 [1.01; 1.29] in obese and 1.00 [0.88; 1.13] in non-obese participants). Here, LEP is linked to type 2 diabetes mellitus.