IL6 and stroke disorder: However, if we include the serum IL-6 levels in the model, the significance of the previous inflammation markers almost completely disappears, but it is significant for the IL-6 (OR: 1.1; CI 95%: 1.04 1.18, p = 0.002) as we can see in Table 2, Model B. Then, high plasma levels of IL-6 are associated with an increased risk of presenting a wake-up IS; the inclusion of IL-6 levels cancels the association of vitamin D levels with stroke upon waking.