Moreover, based on the KEGG enrichment analysis, our results showed characteristic activation of signaling pathways at different stages of RP development, specially, p53 and metabolism-related signaling pathways activated in the acute phase, and PI3K/Akt, cytokine/chemokine signaling and ECM-receptor signaling pathways mainly activated in the subacute and chronic phases, suggesting that targeting these specifically activated signaling pathways at different stages of disease development might achieve better therapeutic effects of RP. Here, TP53 is linked to retinitis pigmentosa 1.