The clinical diagnosis of NF2 is based on the Manchester criteria4, which are (1) BVS, or (2) family history and UVS, or (3) family history or UVS and two of: meningioma, cataract, glioma, neurofibroma, schwannoma, cerebral calcification (if UVS +  ≥ 2 schwannomas only need negative LZTR1 test), or 4) multiple meningioma (2 or more) and two of: UVS, cataract, glioma, neurofibroma, schwannoma, cerebral calcification, and or (5) Constitutional pathogenic NF2 gene variant in blood or identical in two tumours (Supplementary Table 1). Here, NF2 is linked to Cerebral calcification.