ARC and schizophrenia: For example: Kcns2, Kcnb1, and Calm2 are involved in regulating the hyperpolarizing effects of K+ channels;40,41NOS1AP has been shown to cause NMDA receptor dysregulation associated with Schizophrenia;42–44 Arc increases the AMPA receptor endocytosis;45–47Rab27b, Lin7a (previously known target24), Syt12 function relates to synaptic vesicle intracellular transport and exocytosis; and Crh, Tac1 are neuropeptide and neurohormone.